The Mathison family faced their most severe trial in September 2019, when Cameron announced he had been diagnosed with renal cell carcinoma, an aggressive form of kidney cancer. Lucas, who was 16 years old at the time, was thrust into a caregiving support role alongside his mother and sister.
Cameron underwent partial nephrectomy surgery to remove the tumor, followed by months of dietary restructuring, rest, and rehabilitation. In interviews following his recovery, Cameron credited Lucas and Leila for keeping the household centered. The children helped manage domestic routines, monitored their father's physical exertion during recovery walks, and maintained normalcy during an intensely frightening period. Cameron publicly praised his children as "resilient pillars" whose steady composure kept him focused on healing.