LuPone's broad cultural curiosity has often led her toward Jewish traditions and stories. Her performance as Rabbi Dorothy Feinberg in the acclaimed musical comedy series Crazy Ex-Girlfriend earned universal praise, particularly for her energetic performance of the bar mitzvah anthem "Remember That We Suffered."
The portrayal felt authentic because LuPone has spent her life working alongside Jewish writers, composers, and artists who defined the American musical theater canon, from Stephen Sondheim to David Mamet. She has repeatedly expressed admiration for the Jewish tradition of makhloket, constructive argument and wrestling with the divine, contrasting it favorably with the blind obedience demanded by authoritarian religious systems.
Her personal spiritual beliefs are closer to a secular humanism grounded in wonder. Speaking with The Guardian during her West End run in Company, she dismissed the idea of an afterlife spent on golden clouds, pointing instead to the tangible reality of the present. LuPone looks for grace inside the rehearsal room, the discipline of the craft, and the unspoken communion between an actor and an audience sitting together in the dark.