Thirty-six years after the original film became a runaway hit, O'Hara returned to the role for the 2024 sequel, Beetlejuice Beetlejuice. Reunited with Burton, Keaton, and Ryder, she slipped back into Delia’s dramatic cadence as if no time had elapsed. By 2024, Delia had transformed into an even more extravagant, high-concept gallery artist operating in modern Manhattan.
The sequel earned more than $450 million at the worldwide box office, fueled in large part by the multi-generational chemistry between O'Hara, Ryder, and new cast addition Jenna Ortega. Critics singled out O'Hara’s unapologetic, theatrical dedication to the role, noting that her character's narcissism remained completely charming. The project served as a victory lap for her decades-long creative kinship with Burton and Ryder.